Third year B. Pharm (Sem V) Organic Chemistry study material

Handwritten old Answerkey Answer Key_2018 TY OC CBSGS-ANSWER KEY FOR TY BPHARM-SEM-V-Nov-2016

Apr 2017 TY SEM V(CBGS) OC III Apr 2019 T.Y. B. of Pharmacy (Sem V)(CBSGS)  66001 - Organic Chemistry-III Apr 2019 T.Y. B. of Pharmacy (Sem V)(Choice Based)  66101  Organic Chemistry III Nov 2017 T.Y. B Pharm (Sem V)(CBSGS) - Organic Chemistry-III Nov 2018 T.Y. B. of Pharmacy (Sem V)(CBSGS)  66001  Organic Chemistry III Nov 2018 T.Y.B.Pharm (Sem-V) (Choice Based)  66101  Organic Chemistry- III

Polymers Chain growth polymers (free radical polymerization) Stereochemistry of polymerization Ziegler Natta catalyst, co-polymer, step growth polymers, co-polymers, polymer structure and physical properties, biodegradable polymers, characterization of molecular weight – average molecular weight, molecular weight distribution, size exclusion chromatography Polymers -John-McMurry-ebook material Polymer Presentation-1 Polymer Presentation-2 Synthetic Polymers -Youtube video Chain growth polymers (Free radical polymerization) -Youtube video

2.3 DNA: Merrifield solid phase synthesis of DNA Merrifield solid phase synthesis of DNA

II. Peptides: Isoelectric point, synthesis of alpha amino acids (Strecker synthesis and amidomalonate and reductive amination of alpha keto acids), co-valent bonding in peptides, structure determination of peptides, sequencing of peptides (Edman synthesis, C-terminal residue determination- carboxy peptidase), partial hydrolysis of peptides using chemical (aq. Acids) and enzymatic methods (trypsin and chymotrypsin), synthesis of peptides – protection and deprotection of N and C-terminal amino acids, solution phase and solid phase (Merrifield) peptide synthesis. Peptides Isoelectric point synthesis of alpha amino acids John Mcmurry Peptides Solid Phase Peptide Synthesis : The Basics

Biomolecules: I. Chemistry of Steroids 2.1 Definition of steroids and sterols, numbering and ring letters, orientation of projection formulae, stereochemistry of ring junction and side chain attachments, stereochemistry of substituents in the side chain. 2.2 Types of steroid hormones: androgens, estrogens, progestins, corticosteroids. Structure and biosynthesis of steroids from cholesterol. Confirmation and chemical reactivity, steroid specific reactions of A and B rings, Addition-elimination, epoxide opening, relative rates of esterification, oxidation of epimeric alcohols, reduction of ketones. Topic 2.1 Steroid Nomenclature and stereochemistry Introduction of steroids  steroid specific reactions of A and B rings Steroids - Structure & Reactions Reactions of Steroids

1.6 Non-aromatic heterocyclic chemistry: Synthesis and properties of the following heterocycles- Morpholines, Piperazines, Piperidine Non-aromatic heterocyclic chemistry

1.5 Fused heterocycles with One heteroatom a. Quinoline: Synthetic methods including Skraup synthesis, Doebner-Miller synthesis, Friedlander synthesis, Conrad-Limpach synthesis. Reactions with acids, Electrophilic Aromatic Substitution (EAS), nucleophiles, oxidizing and reducing agents b. Isoquinoline: Synthetic methods including Bischler-Napieralski and Pomeranz-Fritsch, Reactions including EAS, nucleophiles, oxidizing and reducing agents. c. Indole: Synthesis by Fischer indole synthesis, Madelung synthesis. Reactions with acids, EAS, Metallic K, Mannich reaction, oxidizing and reducing agents. Quinoline, Isoquinoline  Indole

1.4 Six membered heterocycles with One and Two heteroatoms: a. Pyridine: Synthetic methods including synthesis using 1,5-diketones and Hantzsch synthesis. b. Pyrimidine: Synthesis using malonic ester; 2,4-dichloropyridine, amidine and maleic acid, Reactions of pyridine and pyrimidine with acids, Electrophilic Aromatic Substitution (EAS), nucleophilic aromatic substitution (NAS), Hetaryne formation, oxidizing and reducing agents and Reactions of pyridine-N-oxide  Pyridine & Pyrimidine

1.3. Five membered heterocycles with Two heteroatoms: a. Imidazole: Synthetic methods including synthesis from imidazolines, α-haloketones, Radiszewskii reaction. b. Oxazole: reaction between acid amides and α-halogenoketones eg. Acetamide and bromoacetone form 2,4-dimethyloxazole, Robinson–Gabriel synthesis by dehydration of 2-acylaminoketones, Reaction with Tosylmethyl isocyanide and aldehydes (The Van Leusen reaction) c. Thiazole: preparation α-chlorocarbonyl compound and thioacid amide– Hantzsch synthesis, Gabriel synthesis by reaction of a-Acylamino Ketones with Phosphorus Pentasulfide, Cook-Heilborn’s synthesis from a-Aminonitriles, Reactions of Imidazole, Thiazole, Oxazole with acids, Electrophilic Aromatic Substitution (EAS), nucleophilic aromatic substitution (NAS), oxidizing and reducing agents Imidazole, Oxazole & Thiazole

1.2 Five membered Heterocycles with One Heteroatom: a. Furan: Synthetic methods including synthesis using carbohydrates, Paal-Knorr synthesis b. Pyrrole: Synthetic methods including synthesis using furan, Knorr synthesis, Paal-Knorr synthesis, Hantzsch synthesis. c. Thiophene: Synthetic methods including synthesis using Paal-Knorr synthesis. Reactions of Furan, Pyrrole, and Thiophene: With acids, Electrophilic Aromatic Substitution (EAS), Nucleophilic Aromatic Substitution (NAS) reaction, oxidizing and reducing agents. Pyrrole, Furan & Thiophene

Topic 1.1 Nomenclature of mono, bi- and tri-cyclic hetero-aromatic, fused heterocyclic ring and bridge head system of the drug molecules along with drug examples. Heterocyclic Chemistry-Nomenclature Nomenclature Nomenclature Presentation

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