2.2 Biomolecules: Peptides
II. Peptides: Isoelectric point, synthesis of alpha amino acids (Strecker synthesis and amidomalonate and reductive amination of alpha keto acids), co-valent bonding in peptides, structure determination of peptides, sequencing of peptides (Edman synthesis, C-terminal residue determination- carboxy peptidase), partial hydrolysis of peptides using chemical (aq. Acids) and enzymatic methods (trypsin and chymotrypsin), synthesis of peptides – protection and deprotection of N and C-terminal amino acids, solution phase and solid phase (Merrifield) peptide synthesis. Peptides Isoelectric point synthesis of alpha amino acids John Mcmurry Peptides Solid Phase Peptide Synthesis : The Basics
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